Cell Line Development for Antibodies and Complex Proteins
We aren't just a CDMO for standard antibodies, we also specialize in taking on the complex molecules (bispecifics, trispecifcs, FC-fusions, and more). With transposase mediated technology that offers more stable, better performing cell pools, we can increase productivity and genetic stability for the industry's most complex molecules and processes.
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Highly Customizable Cell Line Development Services
We utilize optimal technology and processes built around a molecule's needs to get you to IND as fast as possible. Our program also features:
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Transfection to IND in 11 months
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Monoclonal antibody titers up to 8 grams / liter; complex proteins multichain molecules up to 4-8 grams / liter
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Transposase-mediated cell line technology with targeted integration & highly productive and stable pools
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Developability assessment to screen multiple protein variants upfront (with stable pool generation for each)
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Research cell bank (RCB), master cell bank (MCB), cGMP cell banking services
Protein Expression Processes Built with GMP Goals in Mind
Preparing proteins for manufacturing starts at the cell line development stage, and requires expertise, customization, and a clear plan to reach clinical manufacturing.
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Cell line development and process development scientists work collaboratively and use shared expertise to efficiently guide your molecule into GMP production
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Customized analytical formulation that includes early sequence and structural analysis for rapid analytics and analytical panels to assess risk and minimize issues at GMP stages
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We have fed-batch, perfusion, and N-1 perfusion manufacturing technology, guide your selection of production technology when you reach clinical manufacturing
Atypical Protein Expression White Paper
Explore how we solve challenges in cell line development with transposase technology
Webinar: Optimizing Processes for Complex Proteins
Our panel of experts discusses how to optimize development and manufacturing of complex proteins, without sacrificing timeline and key quality attributes
We integrated ATUM's industry-leading Leap-In Transposase® expression platform into our cell line development portfolio, giving us highly productive and stable pools that are predictive of final clone titers. This helps us begin process development work earlier and reduce stability screenings, helping accelerate timelines for your project.
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CLD technology that has supported 40+ IND filings
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Active in 40+ licenses on the market
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Approved in 3 global jurisdictions
Microbial Expression Systems Services
Our cell line and strain development capabilities include:
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Full strain development for E. coli systems at our Heidelberg facility
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Demonstrated expertise with with common expression systems like E. coli and Pichia pastoris, Pseudomonas fluorescens (PFEnex system),Bacillus and L. Casei
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Expertise in both soluble and inclusion body expression systems
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Cell line stability analyses
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cGMP cell banking and storage services
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Scientific guidance for your product and process to help it reach GMP production
