Research Article:
Cystine and tyrosine feed reduces oxidative and ER stress in CHO cell Production

Overview

This research article discusses the results of adding Tyr and Cystine to CHO cells and how they affected viability, growth, and mAb productivity due to endoplasmic reticulum (ER) stress and ER -associated degradation (ERAD). 

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This research includes:

• Study for CHO fed-batch culture for omics
• CHO batch culture with coenzyme Q10
• Transcriptomic and proteomic profiling of CHO cells
• Oxidative stress level analysis

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This article was originally published with Biotechnology Journal in May 2023.